Role of RAD51AP1 in homologous recombination DNA repair and carcinogenesis
نویسندگان
چکیده
منابع مشابه
Homologous Recombination and Its Role in Carcinogenesis
Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into precancerous clones. Over the last decade, many studies have revealed the relevance of genomic mutation in this process, be it by misreplication, enviro...
متن کاملSnapShot: Homologous Recombination in DNA Double-Strand Break Repair
Homologous recombination (HR) provides an important mechanism to repair both accidental and programmed DNA double-strand breaks (DSBs) during mitosis and meiosis. Defects in HR are associated with mutagenesis and predispose to cancer, highlighting the importance of this pathway for preserving genome integrity (Moynahan and Jasin, 2010). HR is active in the S and G2 phases of the cell cycle wher...
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DEK is a highly conserved chromatin-bound protein whose upregulation across cancer types correlates with genotoxic therapy resistance. Loss of DEK induces genome instability and sensitizes cells to DNA double strand breaks (DSBs), suggesting defects in DNA repair. While these DEK-deficiency phenotypes were thought to arise from a moderate attenuation of non-homologous end joining (NHEJ) repair,...
متن کاملHomologous recombination as a mechanism of carcinogenesis.
Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into pre-cancerous clones. Over the last decade many studies have revealed the relevance of genomic mutation in this process, be it by misreplication, enviro...
متن کاملGenome-wide Transcriptome Profiling of Homologous Recombination DNA Repair
Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA damage-inducing therapeutics. Here we identify an HR defect (HRD) gene signature that can be used to functionally assess HR repair status without interrogating individual genetic alterations in cells. By using this HRD gene signature as a functional network analysis tool, w...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2017
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2017.09.008